Front Cover Picture: Palladium‐Catalyzed Regioselective C−H Arylation of 4‐Azaindazole at C3, C5 and C7 Positions (Adv. Synth. Catal. 16/2021)

Hindered aryl bromides for regioselective palladium-catalysed direct arylation at less favourable C5-carbon of 3-substituted thiophenes

The use of the congested aryl bromide 2-bromo-1,3-dichlorobenzene as coupling partner allows to modify the regioselectivity of the arylation of 3-substituted thiophene derivatives in favour of carbon C5. The coupling of this aryl bromide with a variety of 3-substituted thiophenes gave in all cases the desired 5-arylation products in moderate to good yields using only 0.5 mol % of a phosphine-fr...

The C345c Domain of C5 Recombinant Factor I Modules of C7 Bind to Complement Components C5 and C7

Cervical diskography: analysis of provoked responses at C2-C3, C3-C4, and C4-C5.

BACKGROUND AND PURPOSE Previous authors have described the locations of provoked responses to cervical diskography from C3-C4 to C6-C7, but we have found no description of the findings at C2-C3. This study was undertaken to analyze the sensations provoked during cervical diskography at C2-C3 and to compare the results with those provoked at C3-C4 and C4-C5. METHODS The locations of diskograph...

C3, C4 and C5: the thioester site.

with a hydrophobic cluster of Tyr-59, Ile-60 and Leu-63 on one surface. It is this hydrophobic cluster that we suggest is being mimicked by the tryptophanyl-tryptophan groups as illustrated in Fig. 1. We also propose that the hydrophobic cluster in C3a represents a secondary binding site on the molecule, and it is a cooperative interaction on the receptor between the hydrophobic and effector si...

C7-Derivatization of C3-Alkylindoles Including Tryptophans and Tryptamines

A versatile strategy for C7-selective boronation of tryptophans, tryptamines, and 3-alkylindoles by way of a single-pot C2/C7-diboronation-C2-protodeboronation sequence is described. The combination of a mild iridium-catalyzed C2/C7-diboronation followed by an in situ palladium-catalyzed C2-protodeboronation allows efficient entry to valuable C7-boroindoles that enable further C7-derivatization...